diff --git a/COMPILING.md b/COMPILING.md
index de3cbb026c1..b7df1319beb 100644
--- a/COMPILING.md
+++ b/COMPILING.md
@@ -44,11 +44,11 @@ This section is only necessary if you are making changes to the code
 generation. Most users only need to use `skipCodegen=true` as discussed above.
 
 ### Build Protobuf
-The codegen plugin is C++ code and requires protobuf 21.7 or later.
+The codegen plugin is C++ code and requires protobuf 22.5 or later.
 
 For Linux, Mac and MinGW:
 ```
-$ PROTOBUF_VERSION=21.7
+$ PROTOBUF_VERSION=22.5
 $ curl -LO https://github.com/protocolbuffers/protobuf/releases/download/v$PROTOBUF_VERSION/protobuf-all-$PROTOBUF_VERSION.tar.gz
 $ tar xzf protobuf-all-$PROTOBUF_VERSION.tar.gz
 $ cd protobuf-$PROTOBUF_VERSION
diff --git a/buildscripts/grpc-java-artifacts/Dockerfile b/buildscripts/grpc-java-artifacts/Dockerfile
index 736babe9d8e..6df0a39bc47 100644
--- a/buildscripts/grpc-java-artifacts/Dockerfile
+++ b/buildscripts/grpc-java-artifacts/Dockerfile
@@ -3,6 +3,7 @@ FROM almalinux:8
 RUN yum install -y \
             autoconf \
             automake \
+            cmake \
             diffutils \
             gcc-c++ \
             glibc-devel \
diff --git a/buildscripts/grpc-java-artifacts/Dockerfile.multiarch.base b/buildscripts/grpc-java-artifacts/Dockerfile.multiarch.base
index 8f7cfae2f52..f9d4fb4fcc3 100644
--- a/buildscripts/grpc-java-artifacts/Dockerfile.multiarch.base
+++ b/buildscripts/grpc-java-artifacts/Dockerfile.multiarch.base
@@ -4,6 +4,7 @@ RUN export DEBIAN_FRONTEND=noninteractive && \
     apt-get update && \
     apt-get upgrade -y && \
     apt-get install -y --no-install-recommends \
+        cmake \
         build-essential \
         ca-certificates \
         curl \
diff --git a/buildscripts/grpc-java-artifacts/Dockerfile.ubuntu2004.base b/buildscripts/grpc-java-artifacts/Dockerfile.ubuntu2004.base
index 2d11d76c373..126a417b58f 100644
--- a/buildscripts/grpc-java-artifacts/Dockerfile.ubuntu2004.base
+++ b/buildscripts/grpc-java-artifacts/Dockerfile.ubuntu2004.base
@@ -4,6 +4,7 @@ RUN export DEBIAN_FRONTEND=noninteractive && \
     apt-get update && \
     apt-get upgrade -y && \
     apt-get install -y --no-install-recommends \
+        cmake \
         build-essential \
         ca-certificates \
         curl \
diff --git a/buildscripts/kokoro/android-interop.sh b/buildscripts/kokoro/android-interop.sh
index b4adc8bed43..f987aea85f6 100755
--- a/buildscripts/kokoro/android-interop.sh
+++ b/buildscripts/kokoro/android-interop.sh
@@ -7,8 +7,8 @@ set -exu -o pipefail
 
 cd github/grpc-java
 
-export LDFLAGS=-L/tmp/protobuf/lib
-export CXXFLAGS=-I/tmp/protobuf/include
+export LDFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --libs protobuf)"
+export CXXFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --cflags protobuf)"
 export LD_LIBRARY_PATH=/tmp/protobuf/lib
 export OS_NAME=$(uname)
 
diff --git a/buildscripts/kokoro/android.sh b/buildscripts/kokoro/android.sh
index 13983e747b7..08e564458a3 100755
--- a/buildscripts/kokoro/android.sh
+++ b/buildscripts/kokoro/android.sh
@@ -9,8 +9,8 @@ BASE_DIR="$(pwd)"
 
 cd "$BASE_DIR/github/grpc-java"
 
-export LDFLAGS=-L/tmp/protobuf/lib
-export CXXFLAGS=-I/tmp/protobuf/include
+export LDFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --libs protobuf)"
+export CXXFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --cflags protobuf)"
 export LD_LIBRARY_PATH=/tmp/protobuf/lib
 export OS_NAME=$(uname)
 
diff --git a/buildscripts/kokoro/unix.sh b/buildscripts/kokoro/unix.sh
index 1b88b56ab40..9d0cd5ac493 100755
--- a/buildscripts/kokoro/unix.sh
+++ b/buildscripts/kokoro/unix.sh
@@ -51,9 +51,9 @@ fi
 export GRADLE_OPTS="-Dorg.gradle.jvmargs='-Xmx1g'"
 
 # Make protobuf discoverable by :grpc-compiler
+export LDFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --libs protobuf)"
+export CXXFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --cflags protobuf)"
 export LD_LIBRARY_PATH=/tmp/protobuf/lib
-export LDFLAGS=-L/tmp/protobuf/lib
-export CXXFLAGS="-I/tmp/protobuf/include"
 
 ./gradlew grpc-compiler:clean $GRADLE_FLAGS
 
diff --git a/buildscripts/make_dependencies.bat b/buildscripts/make_dependencies.bat
index 2bbfd394d46..5c801fa56f9 100644
--- a/buildscripts/make_dependencies.bat
+++ b/buildscripts/make_dependencies.bat
@@ -1,5 +1,7 @@
-set PROTOBUF_VER=21.7
-set CMAKE_NAME=cmake-3.3.2-win32-x86
+@rem set PROTOBUF_VER=21.7
+set PROTOBUF_VER=22.5
+set ABSL_VERSION=20230125.4
+set CMAKE_NAME=cmake-3.26.3-windows-x86_64
 
 if not exist "protobuf-%PROTOBUF_VER%\build\Release\" (
   call :installProto || exit /b 1
@@ -20,9 +22,14 @@ if not exist "%CMAKE_NAME%" (
 set PATH=%PATH%;%cd%\%CMAKE_NAME%\bin
 :hasCmake
 @rem GitHub requires TLSv1.2, and for whatever reason our powershell doesn't have it enabled
-powershell -command "$ErrorActionPreference = 'stop'; & { [Net.ServicePointManager]::SecurityProtocol = [Net.SecurityProtocolType]::Tls12 ; iwr https://github.com/google/protobuf/archive/v%PROTOBUF_VER%.zip -OutFile protobuf.zip }" || exit /b 1
+powershell -command "$ErrorActionPreference = 'stop'; & { [Net.ServicePointManager]::SecurityProtocol = [Net.SecurityProtocolType]::Tls12 ; iwr https://github.com/google/protobuf/releases/download/v%PROTOBUF_VER%/protobuf-%PROTOBUF_VER%.zip -OutFile protobuf.zip }" || exit /b 1
 powershell -command "$ErrorActionPreference = 'stop'; & { Add-Type -AssemblyName System.IO.Compression.FileSystem; [System.IO.Compression.ZipFile]::ExtractToDirectory('protobuf.zip', '.') }" || exit /b 1
 del protobuf.zip
+powershell -command "$ErrorActionPreference = 'stop'; & { [Net.ServicePointManager]::SecurityProtocol = [Net.SecurityProtocolType]::Tls12 ; iwr https://github.com/abseil/abseil-cpp/archive/refs/tags/%ABSL_VERSION%.zip -OutFile absl.zip }" || exit /b 1
+powershell -command "$ErrorActionPreference = 'stop'; & { Add-Type -AssemblyName System.IO.Compression.FileSystem; [System.IO.Compression.ZipFile]::ExtractToDirectory('absl.zip', '.') }" || exit /b 1
+del absl.zip
+rmdir protobuf-%PROTOBUF_VER%\third_party\abseil-cpp
+rename abseil-cpp-%ABSL_VERSION% protobuf-%PROTOBUF_VER%\third_party\abseil-cpp
 mkdir protobuf-%PROTOBUF_VER%\build
 pushd protobuf-%PROTOBUF_VER%\build
 
diff --git a/buildscripts/make_dependencies.sh b/buildscripts/make_dependencies.sh
index 3d02a72f4eb..32d8f8db69f 100755
--- a/buildscripts/make_dependencies.sh
+++ b/buildscripts/make_dependencies.sh
@@ -3,13 +3,16 @@
 # Build protoc
 set -evux -o pipefail
 
-PROTOBUF_VERSION=21.7
+PROTOBUF_VERSION=22.5
+ABSL_VERSION=20230125.4
 
 # ARCH is x86_64 bit unless otherwise specified.
 ARCH="${ARCH:-x86_64}"
 DOWNLOAD_DIR=/tmp/source
 INSTALL_DIR="/tmp/protobuf-cache/$PROTOBUF_VERSION/$(uname -s)-$ARCH"
+BUILDSCRIPTS_DIR="$(cd "$(dirname "$0")" && pwd)"
 mkdir -p $DOWNLOAD_DIR
+cd "$DOWNLOAD_DIR"
 
 # Start with a sane default
 NUM_CPU=4
@@ -26,27 +29,42 @@ if [ -f ${INSTALL_DIR}/bin/protoc ]; then
   echo "Not building protobuf. Already built"
 # TODO(ejona): swap to `brew install --devel protobuf` once it is up-to-date
 else
-  if [[ ! -d "$DOWNLOAD_DIR"/protobuf-"${PROTOBUF_VERSION}" ]]; then
-    curl -Ls https://github.com/google/protobuf/releases/download/v${PROTOBUF_VERSION}/protobuf-all-${PROTOBUF_VERSION}.tar.gz | tar xz -C $DOWNLOAD_DIR
+  if [[ ! -d "protobuf-${PROTOBUF_VERSION}" ]]; then
+    curl -Ls "https://github.com/google/protobuf/releases/download/v${PROTOBUF_VERSION}/protobuf-${PROTOBUF_VERSION}.tar.gz" | tar xz
+    curl -Ls "https://github.com/abseil/abseil-cpp/archive/refs/tags/${ABSL_VERSION}.tar.gz" | tar xz
+    rmdir "protobuf-$PROTOBUF_VERSION/third_party/abseil-cpp"
+    mv "abseil-cpp-$ABSL_VERSION" "protobuf-$PROTOBUF_VERSION/third_party/abseil-cpp"
   fi
-  pushd $DOWNLOAD_DIR/protobuf-${PROTOBUF_VERSION}
+  # the same source dir is used for 32 and 64 bit builds, so we need to clean stale data first
+  rm -rf "$DOWNLOAD_DIR/protobuf-${PROTOBUF_VERSION}/build"
+  mkdir "$DOWNLOAD_DIR/protobuf-${PROTOBUF_VERSION}/build"
+  pushd "$DOWNLOAD_DIR/protobuf-${PROTOBUF_VERSION}/build"
   # install here so we don't need sudo
   if [[ "$ARCH" == x86* ]]; then
-    ./configure CFLAGS=-m${ARCH#*_} CXXFLAGS=-m${ARCH#*_} --disable-shared \
-      --prefix="$INSTALL_DIR"
-  elif [[ "$ARCH" == aarch* ]]; then
-    ./configure --disable-shared --host=aarch64-linux-gnu --prefix="$INSTALL_DIR"
-  elif [[ "$ARCH" == ppc* ]]; then
-    ./configure --disable-shared --host=powerpc64le-linux-gnu --prefix="$INSTALL_DIR"
-  elif [[ "$ARCH" == s390* ]]; then
-    ./configure --disable-shared --host=s390x-linux-gnu --prefix="$INSTALL_DIR"
-  elif [[ "$ARCH" == loongarch* ]]; then
-    ./configure --disable-shared --host=loongarch64-unknown-linux-gnu --prefix="$INSTALL_DIR"
+    CFLAGS=-m${ARCH#*_} CXXFLAGS=-m${ARCH#*_} cmake .. \
+      -DCMAKE_CXX_STANDARD=14 -Dprotobuf_BUILD_TESTS=OFF -DBUILD_SHARED_LIBS=OFF \
+      -DCMAKE_INSTALL_PREFIX="$INSTALL_DIR" -DABSL_INTERNAL_AT_LEAST_CXX17=0
+  else
+    if [[ "$ARCH" == aarch_64 ]]; then
+      GCC_ARCH=aarch64-linux-gnu
+    elif [[ "$ARCH" == ppcle_64 ]]; then
+      GCC_ARCH=powerpc64le-linux-gnu
+    elif [[ "$ARCH" == s390_64 ]]; then
+      GCC_ARCH=s390x-linux-gnu
+    elif [[ "$ARCH" == loongarch_64 ]]; then
+      GCC_ARCH=loongarch64-unknown-linux-gnu
+    else
+      echo "Unknown architecture: $ARCH"
+      exit 1
+    fi
+    cmake .. \
+      -DCMAKE_CXX_STANDARD=14 -Dprotobuf_BUILD_TESTS=OFF -DBUILD_SHARED_LIBS=OFF \
+      -DCMAKE_INSTALL_PREFIX="$INSTALL_DIR" -Dcrosscompile_ARCH="$GCC_ARCH" \
+      -DCMAKE_TOOLCHAIN_FILE=$BUILDSCRIPTS_DIR/toolchain.cmake
   fi
-  # the same source dir is used for 32 and 64 bit builds, so we need to clean stale data first
-  make clean
-  make V=0 -j$NUM_CPU
-  make install
+  cmake --build . -j "$NUM_CPU"
+  cmake --install .
+  [ -d "$INSTALL_DIR/lib64" ] && mv "$INSTALL_DIR/lib64" "$INSTALL_DIR/lib"
   popd
 fi
 
@@ -60,7 +78,7 @@ ln -s "$INSTALL_DIR" /tmp/protobuf
 cat <<EOF
 To compile with the build dependencies:
 
-export LDFLAGS=-L/tmp/protobuf/lib
-export CXXFLAGS=-I/tmp/protobuf/include
+export LDFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --libs protobuf)"
+export CXXFLAGS="$(PKG_CONFIG_PATH=/tmp/protobuf/lib/pkgconfig pkg-config --cflags protobuf)"
 export LD_LIBRARY_PATH=/tmp/protobuf/lib
 EOF
diff --git a/buildscripts/toolchain.cmake b/buildscripts/toolchain.cmake
new file mode 100644
index 00000000000..b71515cebda
--- /dev/null
+++ b/buildscripts/toolchain.cmake
@@ -0,0 +1,9 @@
+set(CMAKE_SYSTEM_NAME Linux)
+
+set(CMAKE_C_COMPILER   "${crosscompile_ARCH}-gcc")
+set(CMAKE_CXX_COMPILER "${crosscompile_ARCH}-g++")
+set(CMAKE_FIND_ROOT_PATH "/usr/${crosscompile_ARCH}/")
+
+set(CMAKE_FIND_ROOT_PATH_MODE_PROGRAM NEVER)
+set(CMAKE_FIND_ROOT_PATH_MODE_LIBRARY ONLY)
+set(CMAKE_FIND_ROOT_PATH_MODE_INCLUDE ONLY)
diff --git a/compiler/build.gradle b/compiler/build.gradle
index 3c8e9358401..53e0fd641e3 100644
--- a/compiler/build.gradle
+++ b/compiler/build.gradle
@@ -100,7 +100,7 @@ model {
         all {
             if (toolChain in Gcc || toolChain in Clang) {
                 cppCompiler.define("GRPC_VERSION", version)
-                cppCompiler.args "--std=c++0x"
+                cppCompiler.args "--std=c++14"
                 addEnvArgs("CXXFLAGS", cppCompiler.args)
                 addEnvArgs("CPPFLAGS", cppCompiler.args)
                 if (osdetector.os == "osx") {