diff --git a/ci/requirements/doc.yml b/ci/requirements/doc.yml
index d483372..5e5e9d2 100644
--- a/ci/requirements/doc.yml
+++ b/ci/requirements/doc.yml
@@ -15,6 +15,7 @@ dependencies:
   - sphinx-autosummary-accessors
   - sphinx-copybutton
   - xarray
+  - xarray-datatree
   # For examples
   - adlfs
   - ipykernel
diff --git a/ci/requirements/environment.yml b/ci/requirements/environment.yml
index 3e0b102..7ca4663 100644
--- a/ci/requirements/environment.yml
+++ b/ci/requirements/environment.yml
@@ -16,6 +16,7 @@ dependencies:
   - pytest-cov
   - pytorch
   - tensorflow
+  - xarray-datatree
   - zarr
   # Style checks
   - black
diff --git a/pyproject.toml b/pyproject.toml
index 11ab076..99141fc 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -30,6 +30,7 @@ dependencies = [
     "xarray",
 ]
 [project.optional-dependencies]
+datatree = ["xarray-datatree"]
 torch = [
     "torch",
 ]
@@ -44,6 +45,7 @@ dev = [
     "pytest-cov",
     "tensorflow",
     "torch",
+    "xarray-datatree",
 ]
 [project.urls]
 documentation = "https://xbatcher.readthedocs.io/en/latest/"
@@ -58,7 +60,7 @@ fallback_version = "999"
 
 [tool.isort]
 profile = "black"
-known_third_party = ["numpy", "pandas", "pytest", "sphinx_autosummary_accessors", "torch", "xarray"]
+known_third_party = ["datatree", "numpy", "pandas", "pytest", "sphinx_autosummary_accessors", "torch", "xarray"]
 
 [tool.pytest.ini_options]
 log_cli = true
diff --git a/xbatcher/__init__.py b/xbatcher/__init__.py
index 6fb8d75..19f32ad 100644
--- a/xbatcher/__init__.py
+++ b/xbatcher/__init__.py
@@ -3,7 +3,11 @@
 
 from . import testing  # noqa: F401
 from .accessors import BatchAccessor  # noqa: F401
-from .generators import BatchGenerator, BatchSchema  # noqa: F401
+from .generators import (  # noqa: F401
+    BatchGenerator,
+    BatchSchema,
+    datatree_slice_generator,
+)
 from .util.print_versions import show_versions  # noqa: F401
 
 try:
diff --git a/xbatcher/generators.py b/xbatcher/generators.py
index 58799ba..07c3a1b 100644
--- a/xbatcher/generators.py
+++ b/xbatcher/generators.py
@@ -7,6 +7,7 @@
 
 import numpy as np
 import xarray as xr
+from datatree import DataTree
 
 PatchGenerator = Iterator[Dict[Hashable, slice]]
 BatchSelector = List[Dict[Hashable, slice]]
@@ -462,3 +463,73 @@ def __getitem__(self, idx: int) -> Union[xr.Dataset, xr.DataArray]:
                 )
         else:
             raise IndexError("list index out of range")
+
+
+def datatree_slice_generator(
+    data_obj: DataTree,
+    dim_strides: Dict[str, int],
+    ref_node: str,
+    **kwargs,
+) -> DataTree:
+    """
+    Generator for iterating through an Xarray DataTree.
+
+    Parameters
+    ----------
+    data_obj : ``datatree.DataTree``
+        The multi-dimensional xarray data object to iterate over.
+
+    dim_strides : dict
+        A dictionary specifying the size of the stride in each dimension to
+        slice along, e.g. ``{'longitude': 30, 'latitude': 30}``. These are the
+        dimensions the machine library will see.
+
+    ref_node : str
+        The reference node in the xarray DataTree object whose minimum and
+        maximum coordinate bounds will be used to iteratively slice over.
+
+    kwargs : dict
+        Extra keyword arguments to pass into datatree.Datatree.sel
+
+    Yields
+    ------
+    xr_slice : : ``datatree.DataTree``
+        A single slice of a multi-dimensional xarray data object.
+    """
+    # Get the coordinate positions to slice on for each dimension, e.g.
+    # {'y': [(45.0, 25.0), (25.0, 5.0)],
+    #  'x': [(95.0, 115.0), (115.0, 135.0), (135.0, 155.0)]}
+    slice_positions: Dict[str, list] = {}
+    for dim, stride in dim_strides.items():
+        first_coord: np.ndarray = data_obj[ref_node].isel({dim: 0})[dim].data
+        final_coord: np.ndarray = data_obj[ref_node].isel({dim: -1})[dim].data
+        slices: int = int(np.floor((final_coord - first_coord) / stride))
+
+        # Obtain slicing positions. Need to minus and plus half a pixel because
+        # xarray uses centre-based coordinates
+        resolution: float = (final_coord - first_coord) / slices
+        start_positions: np.ndarray = np.linspace(
+            start=first_coord - (resolution / 2),
+            stop=final_coord - (resolution / 2),
+            num=slices + 1,
+        )
+        stop_positions: np.ndarray = np.linspace(
+            start=first_coord + (resolution / 2),
+            stop=final_coord + (resolution / 2),
+            num=slices + 1,
+        )
+        slice_positions[dim] = [tup for tup in zip(start_positions, stop_positions)]
+    assert slice_positions.keys() == dim_strides.keys()
+
+    # Iterate over combinations of slice positions across many dimensions, e.g.
+    # ((45.0, 25.0), (95.0, 115.0))
+    # ((45.0, 25.0), (115.0, 135.0))
+    # ((45.0, 25.0), (135.0, 155.0))
+    # ((25.0, 5.0), (95.0, 115.0))
+    # ((25.0, 5.0), (115.0, 135.0))
+    # ((25.0, 5.0), (135.0, 155.0))
+    for slice_pos in itertools.product(*slice_positions.values()):
+        indexers: Dict[str, slice] = {}
+        for i, dim in enumerate(dim_strides):
+            indexers[dim] = slice(*slice_pos[i])
+        yield data_obj.sel(indexers=indexers, **kwargs)
diff --git a/xbatcher/tests/test_datatree.py b/xbatcher/tests/test_datatree.py
new file mode 100644
index 0000000..65168d3
--- /dev/null
+++ b/xbatcher/tests/test_datatree.py
@@ -0,0 +1,80 @@
+import datatree.testing as dtt
+import numpy as np
+import pytest
+import xarray as xr
+from datatree import DataTree
+
+from xbatcher import datatree_slice_generator
+
+
+@pytest.fixture(scope="module")
+def sample_datatree() -> DataTree:
+    """
+    Sample multi-resolution DataTree for testing.
+
+    DataTree('None', parent=None)
+    ├── DataTree('grid10m')
+    │       Dimensions:  (y: 4, x: 6)
+    │       Coordinates:
+    │         * y        (y) float64 40.0 30.0 20.0 10.0
+    │         * x        (x) float64 100.0 110.0 120.0 130.0 140.0 150.0
+    │       Data variables:
+    │           grid10m  (y, x) int64 10 11 12 13 14 15 16 17 18 ... 26 27 28 29 30 31 32 33
+    └── DataTree('grid20m')
+            Dimensions:  (y: 2, x: 3)
+            Coordinates:
+              * y        (y) float64 35.0 15.0
+              * x        (x) float64 105.0 125.0 145.0
+            Data variables:
+                grid20m  (y, x) int64 0 1 2 3 4 5
+    """
+    grid20m = xr.DataArray(
+        data=np.arange(0, 6).reshape(2, 3),
+        dims=("y", "x"),
+        coords={"y": np.linspace(35.0, 15.0, num=2), "x": np.linspace(105, 145, num=3)},
+        name="grid20m",
+    )
+    grid10m = xr.DataArray(
+        data=np.arange(10, 34).reshape(4, 6),
+        dims=("y", "x"),
+        coords={"y": np.linspace(40.0, 10.0, num=4), "x": np.linspace(100, 150, num=6)},
+        name="grid10m",
+    )
+    dt = DataTree.from_dict(d={"grid10m": grid10m, "grid20m": grid20m})
+    return dt
+
+
+@pytest.fixture(scope="module")
+def expected_datatree() -> DataTree:
+    """ """
+    expected_datatree = DataTree.from_dict(
+        d={
+            "grid10m": xr.DataArray(
+                data=[[26, 27], [32, 33]],
+                dims=("y", "x"),
+                coords={"y": [20.0, 10.0], "x": [140.0, 150.0]},
+                name="grid10m",
+            ),
+            "grid20m": xr.DataArray(
+                data=[[5]],
+                dims=("y", "x"),
+                coords={"y": [15.0], "x": [145.0]},
+                name="grid20m",
+            ),
+        }
+    )
+    return expected_datatree
+
+
+def test_datatree(sample_datatree, expected_datatree):
+    """
+    Test slicing through a multi-resolution DataTree.
+    """
+    generator = datatree_slice_generator(
+        data_obj=sample_datatree, dim_strides={"y": -20, "x": 20}, ref_node="grid20m"
+    )
+    for i, chip in enumerate(generator):
+        pass
+
+    assert i + 1 == 6  # number of chips
+    dtt.assert_identical(a=chip, b=expected_datatree)  # check returned DataTree